Scientists create human sperm from stem cells


LONDON - British scientists claimed Wednesday to have created human sperm from embryonic stem cells for the first time, an accomplishment they say may someday help infertile men father children.


The technique could in 10 years allow researchers to use the basic knowledge of how sperm develop to design treatments to enable infertile men the chance to have biological children, said lead researcher Karim Nayernia, of Newcastle University, whose team earlier produced baby mice from sperm derived in a similar way.


The research, published in the journal Stem Cells and Development, was conducted by scientists at Newcastle and the NorthEast England Stem Cell Institute.


Stem cells can become any cell in the body, and scientists have previously turned them into a variety of new entities, including cells from the brain, pancreas, heart and blood vessels.
Some experts challenged the research, saying they weren’t convinced Nayernia and his colleagues had actually produced sperm cells. Several critics also said the sperm cells they created were clearly abnormal.


“I am unconvinced from the data presented in this paper that the cells produced by Professor Nayernia’s group from embryonic stem cells can be accurately called ’spermatazoa,” said Allan Pacey, a senior lecturer in andrology at the University of Sheffield.
Pacey said in a statement that the sperm created by Nayernia did not have the specific shape, movement and function of real sperm.


Azim Surani, a professor of physiology and reproduction at the University of Cambridge said the sperm produced by the Newcastle team were “a long way from being authentic sperm cells.”
Nayernia said the cells “showed all the characteristics of sperm,” but his group’s intention was simply to “open up new avenues of research” with their early findings, rather than using the sperm to fertilize eggs.


Robin Lovell-Badge, a stem cell expert at the National Institute of Medical Research said that despite the questions raised, Nayernia and colleagues may have made some progress in obtaining human sperm from embryonic cells.


Nayernia said creating embryos from lab-manufactured sperm is banned by British law.
He said they only plan to produce sperm to study the reasons behind infertility, and will not fertilize any eggs.


Some lawmakers said provisions should be made to allow sperm derived from stem cells to be tested as part of potential fertility treatments.

Obesity may be a risk factor in swine flu

ATLANTA - Some swine flu cases in Michigan are raising questions about obesity's role in why some people with infections become seriously ill.


A high proportion of those who have gotten severely ill from swine flu have been obese or extremely obese, but health officials have said that might be due to the fact that heavy people tend to have asthma and other conditions that make them more susceptible. Obesity alone has never been seen as a risk factor for seasonal flu.

Meanwhile, the government is ready to announce another $1 billion in orders for swine flu vaccinations.

Health and Human Services Secretary Kathleen Sebelius said Sunday she will announce Monday that Washington has approved another billion dollars to buy components of the vaccine. Sebelius said that research is under way to provide a safe and effective vaccine to fight a flu strain that could be a pandemic.

Sebelius and other top officials are bracing for fall's flu season. She says leaders are watching the Southern Hemisphere for clues how serious the U.S. flu season might be.
Sebelius appeared on CNN's "State of the Union."

Complications in obese patientsIn a report released Friday, health officials detailed the cases of 10 Michigan patients who were very sick from swine flu in late May and early June and ended up at a specialized hospital in Ann Arbor. Three of them died.

Nine of the 10 were either obese or extremely obese. Only three of the 10 had other health problems. Two of the three that died had no other health conditions.

This hardly settles the question of whether obesity is its own risk factor for swine flu. It's possible the patients had undiagnosed heart problems or other unidentified conditions.
Still the finding was striking, investigators acknowledged.

Also remarkable were that five of the patients developed blood clots in their lungs, and six had kidney failure. Those complications have been seen in some swine flu patients before, but not usually in such a high proportion.

"Clinicians need to be aware that severe complications can occur in patients with the novel H1N1 virus, particularly in extremely obese patients," said Dr. Tim Uyeki, a flu expert at the Centers for Disease Control and Prevention.

Uyeki was a co-author of the report, released by a CDC publication, Morbidity and Mortality Weekly Report.

Also on Friday, the CDC said the number of U.S. swine flu cases has surpassed 37,000 and deaths have risen to 211.

The numbers rose from the 170 deaths and nearly 34,000 confirmed and suspected swine flu cases reported last week.

Those are lab-confirmed and probable infections. CDC officials believe those cases — which sought treatment and underwent testing — are just the tip of the iceberg. They estimate more than 1 million Americans have been infected with the virus so far, though many probably had only a mild illness.

Swine flu is the predominant flu type circulating currently, with nine states reporting widespread cases, down from 10 a week ago.

The pandemic was first identified in California in April. Since then a total of more than 94,000 cases have been reported in more than 100 countries, according to the World Health Organization.

Your best face: Beautiful skin at 40 and beyond


The best skin of your life may well be ahead of you. Sure, with each passing decade, you face fresh challenges in your quest for a radiant complexion: There are the newfound crow's feet in your 40s, the postmenopausal dryness in your 50s, and the sagging that sets in by your 60s. But the right products and procedures will prepare you to meet these challenges head-on.
"These days, it's perfectly reasonable to expect your skin to get better as you age — no matter what the date on your driver's license," says Dr. Ranella Hirsch, president of the American Society of Cosmetic Dermatology and Aesthetic Surgery and a cosmetic dermatologist in Cambridge, Mass.
Still, knowing what's right for you — from the most potent creams to the latest lasers — can be confusing. That's where this decade-by-decade guide comes in. It's filled with everything you need to know, including exactly what to use when. Follow along and your skin's future will look very bright.
Your 40s: treat, tone and texture
Best home treatments Embrace retinoids: These vitamin A derivatives boost collagen production (which softens fine lines and minimizes pores). Retinoids rev up sluggish cell turnover, so skin becomes smoother and more radiant, and dark spots fade. Prescription versions such as Renova yield noticeable changes after about eight weeks; retinol, the strongest over-the-counter option, takes 12 weeks. Choose a product formulated with up to 1 percent retinol, the highest amount available OTC, depending on your skin's tolerance. Try Remergent Advanced Retinol Therapy ($56; remergentskin.com) and Roc Retinol Correxion Deep Wrinkle Serum ($20; drugstores). Ease in by using a retinoid every third night for at least two weeks. Apply it every other night for the next two weeks, ramping up to nightly application. Summer's the ideal time to get started on a retinoid — the increased humidity tempers dryness that might occur as your skin acclimates.
Exfoliate regularly: Once you've built up to a nightly retinoid application, boost its benefits by substituting in an alpha-hydroxy acid twice a week. "Both ingredients exfoliate, leaving skin brighter and smoother," says New Orleans-based dermatologist Dr. Mary Lupo. "But because they stimulate cell renewal in different ways, you'll get maximum improvement using both." If skin is dry, choose an AHA formulated with moisturizing lactic acid.
Consider hydroquinone: This agent, which inhibits the production of melanin, is one of the most effective ways to fade blotchiness, says Hirsch. OTC creams contain 2 percent HQ, which lightens subtle discoloration over several months. Rx versions boast 4 percent, and daily spot treatment can diminish dark patches in six to eight weeks. "Keep in mind, though, that a single afternoon spent unprotected in the sun can undo all that hard work," says Wechsler. Use HQ only for three months. After that, maintain results with a skin lightener that contains kojic acid or licorice extract.
Turn to the pros Reduce brown spots: Intense pulsed light (IPL) employs a broad wavelength of light to target brown spots and red areas, destroying them without damaging the upper layers of the skin; you may look a little pink for an hour after treatment. Four to six monthly sessions at about $400 each should be enough to even out your complexion; a maintenance session every 6 to 12 months keeps up the results.
Restore your glow: A series of LED (light-emitting diode) treatments, either on their own or in conjunction with IPL, uses painless light energy to minimize fine lines, reduce pore size, diminish dark spots, and give skin a smoother texture. There's no downtime: You sit in front of a panel of 2,000 tiny pulsing lights for up to 40 minutes; results become more noticeable after three weeks. "LED thickens the skin, so it looks more luminous when light bounces off it," says Dr. David Goldberg, a clinical professor of dermatology and director of laser research at Mount Sinai School of Medicine. A recent study published in the Journal of Drugs in Dermatology also showed that the device promotes new collagen formation and decreases inflammation that causes collagen to break down. Six monthly treatments at about $100 each and twice-yearly touch-ups are recommended.
Erase lines: Botox is the surest way to smooth creases you're already noticing and prevent more. It temporarily relaxes facial muscles so they can't move and create wrinkles. "Botox retrains your muscles, so the effects last longer and longer," says Goldberg. "Some patients who start when they're 45 are coming in only twice a year by the time they're 50." Each treatment costs approximately $400, and results last about 4 months.
Your 50s: hydrate and plump The average age of menopause is 51, and with the drop in hormones, skin becomes parched and brown spots increase. Deeper folds, including the "smile" lines that run from the corners of the nose to the corners of the mouth, develop as skin loses underlying fat. This loss also "hollows out" the under-eye area, says Dr. Kenneth Beer, an assistant professor of dermatology at the University of Miami.
Best home treatmentsSwitch to a gentler cleanser: Replace oil-stripping gel cleansers or bar soaps with a creamy face wash. Choose double-duty moisturizers. "Look for formulas that contain a humectant to draw water in and an occlusive to create a barrier that prevents it from evaporating," says Dr. Arielle Kauvar, a clinical associate professor of dermatology at New York University Medical Center. Try L'Oréal Paris Age-Perfect Pro-Calcium Restorative Hydrating Cream ($20; drugstores) and the Body Shop Wise Woman Regenerating Night Cream ($34; thebodyshop.com).
Rethink your retinoid: If you haven't already, switch to Renova or Atralin; both are moisturizing.
Take care of your eyes: Collagen and fat loss under delicate eye skin makes crow's feet more apparent. Plump lines with a nightly application of an eye cream. Look for one with silicone, an emollient that temporarily "spackles" fine lines, says Dr. Heidi Waldorf, an associate clinical professor of dermatology at Mount Sinai School of Medicine.
Turn to the pros Plump lines and lips: Filling materials injected into your skin enhance hollow areas. For a natural look, choose a filler that contains hyaluronic acid, formulated from a substance found in skin. Both Restylane and Juvederm last about 6 months and are ideal for plumping the smile lines, lips, and under-eye area. Perlane, which is thicker, is used to fill deeper folds and sunken cheeks and lasts up to eight months.
Prevent wrinkles: Botox softens new folds and increases the longevity of fillers by minimizing the muscle movement that can cause them to dissipate.

Arms central to US-Russia talks


US President Barack Obama and his Russian counterpart Dmitry Medvedev are expected to announce nuclear weapons cuts when they meet later in Moscow.
Officials on both sides were quoted as saying a document had been agreed, though Russia said it was not final.
Both men say they want significant cuts - possibly down to 1,500 warheads each.
In addition Russia has been pressing Mr Obama to scrap a US plan for a missile defence shield in Europe. Afghanistan and Iran are also on the agenda. President Obama will hold talks with Vladimir Putin, currently prime minister and formerly president, on Tuesday. Many analysts say he is still in the driving seat in the Russian government.
Both sides have made clear their desire to improve, or "reset", relations between Washington and Moscow.
But BBC diplomatic correspondent Jonathan Marcus, who is in Moscow, says that is not going to be easy given the different perceptions of their national interests the two sides bring to the table.
Under the previous Bush Administration, relations between Washington and Moscow were almost as bad as during the Cold War, so there is ample opportunity for improvement, he adds.
'Difficult situation'
Mr Obama flew out of Andrews Air Force Base aboard Air Force One on Sunday evening, together with his wife and two daughters. He is due to begin his visit by laying a wreath at the Grave of an Unknown Soldier near the Kremlin wall, before talks with Mr Medvedev.
The Russian president said in an interview for Italian media released on Sunday that US missile shield plans for Europe put a "very prominent nuclear country like Russia... in a difficult situation".
Arms control will top the agenda of the summit. The Soviet-era Start I accord expires in December.
The White House co-ordinator for weapons of mass destruction, Gary Samore, ruled out any final agreement on renewing Start being reached this week, but he did see an "announcement" being made.
"I think you will see an announcement that indicates some progress toward reaching that objective," he told reporters.
On Afghanistan, the US is confident of obtaining Moscow's approval for flying troops and weapons through Russian airspace.
President Obama will also meet Russian journalists and civil society activists.
Low-key feel
A University of Maryland opinion poll released on Sunday suggests that 75% of Russians believe the US abuses its greater power and only 2% have "a lot of confidence" that Mr Obama will do the right thing in world affairs. Neither of Russia's main TV news bulletins on Sunday evening led with the impending US visit.
"This is being played as essentially a low-key visit that shows the American leadership's respect for the Russian leadership," Dmitry Trenin, head of the Moscow Carnegie Centre think-tank, told Reuters news agency.
"This is not some star coming to town."
Nonetheless, correspondents say Mr Obama can expect a smoother reception than he received on a 2005 visit to Russia when he and other visiting US Congressmen were detained for three hours at an airport in the Urals city of Perm.
They were kept in an "uncomfortably stuffy room adjacent to the tarmac", a US spokesman said, as they resisted Russian customs officials' demands to search their plane.
Mr Obama later brushed off the incident in his book The Audacity of Hope, saying "It wasn't the Gulag".

NKorean launches maybe included new Scud


SEOUL, South Korea (AP) — A barrage of ballistic missiles that North Korea test-fired over the weekend may have included a new type of Scud missile with an extended range and improved accuracy that poses a threat to Japan, a South Korean newspaper reported Monday.

Pyongyang launched seven missiles into waters off its east coast Saturday in a show of force that defied U.N. resolutions and drew international condemnation.

On Monday, South Korea's mass-circulation Chosun Ilbo newspaper reported the launches were believed to have included three Scud-ER missiles with a range of up to 620 miles (1,000 kilometers).

The paper said the Scud-ER has a longer range and better accuracy compared with previous Scud series so is "particularly a threat to Japan."

Tokyo is about 720 miles (1,160 kilometers) from the base on North Korea's east coast from where the missiles were fired. Some other parts of Japan are closer, well within the range of a Scud-ER.

Scuds are single stage, liquid-fueled missiles, originally developed in the former Soviet Union, and generally known for poor accuracy. Ballistic missile programs in Pakistan and Iran were built on Scud technology.

The Chosun Ilbo, citing a government source it did not name, said the other four missiles were two Scud-C missiles with a range of 310 miles (500 kilometers) and two medium-range Rodong missiles that can travel up to 810 miles (1,300 kilometers).

Five of the seven missiles flew about 260 miles (420 kilometers) from an eastern coastal launch site and landed in one area, meaning their accuracy has improved, the paper said.

South Korea's Defense Ministry spokesman Won Tae-jae said Monday that the North demonstrated improved missile accuracy in the latest tests because they all landed in the same area.

He declined to confirm details of the Chosun Ilbo report.

Another ministry official told The Associated Press on Sunday that the missiles appeared to have traveled about 250 miles (400 kilometers), meaning that key government and military facilities in South Korea were within range. The official spoke on condition of anonymity citing department policy.

North Korea has long-range missiles as well. The Taepodong-2 has a potential range of more than 4,100 miles (6,700 kilometers), putting Alaska within striking distance.

The country is believed to be developing a missile with an even longer range that could potentially put the U.S. west coast, Hawaii, Australia and eastern Europe within striking distance.

The launches on July 4 — the U.S. Independence Day holiday — also appeared to be a poke at Washington as it moves to enforce U.N. as well as its own sanctions against the isolated regime for its May 25 nuclear test.

Adm. Mike Mullen, chairman of the U.S. Joint Chiefs of Staff, warned they were "very destabilizing, potentially."

North Korean state media have not specifically mentioned the launches but boasted Sunday that the country's military could impose "merciless punishment" on those who provoke it.

"Our revolutionary forces have grown up today as the strong army that can impose merciless punishment against those who offend us," the North's main Rodong Sinmun newspaper said in a commentary carried by the official Korean Central News Agency.

The North has engaged in a series of acts this year widely seen as provocative. It fired a long-range rocket it said was a satellite in early April, and in late May it carried out its second underground nuclear test following the first in late 2006.

The U.N. Security Council punished Pyongyang with tough sanctions centered on clamping down on North Korea's alleged trading of banned arms and weapons-related material.

The U.S. has been monitoring a North Korean freighter because of suspicions it may be carrying illegal weapons, possibly to Myanmar. The ship, however, turned around a week ago without stopping at any port and headed toward home.

Won, the Defense Ministry spokesman, said the Kang Nam 1 was expected to arrived in the North later Monday.

Separately, in Kuala Lumpur, Malaysian Foreign Minister Anifah Aman pledged to work with the U.S. to block North Korea from using the Southeast Asian nation's banks for any weapons deals.

The assurance came as U.S. envoy Philip Goldberg, in charge of coordinating the implementation of sanctions against Pyongyang, met with Malaysian officials in Kuala Lumpur.

South Korean media have reported that North Korea sought payment through a bank in Malaysia for a suspected shipment of weapons to Myanmar.

Kevin Jonas Gets Engaged!


Kevin Jonas surprised his girlfriend Danielle Deleasa by showing up at her doorstep in New Jersey early Wednesday morning and dropping down to his knee to ask her to marry him. Presented with a cushion-cut diamond ring that Jonas designed with Jacob & Co., Deleasa couldn't believe what was happening. Then, "She said yes, yes, yes like 500 times super fast in a row," the oldest of the Jonas Brothers tells PEOPLE exclusively. Jonas, 21, and Deleasa, 22, who met in May of 2007 while vacationing with their families in the Bahamas, haven't set a wedding date yet. "It still feels like a dream," she tells PEOPLE.
Overnight FlightWhen Deleasa, a former hairdresser, first met Jonas two years ago, she admits, "I didn't know who the Jonas Brothers were." It was Kevin who eagerly pursued her after meeting her and then spotting her walking on the beach with a flower in her hair. Jonas popped the question after arriving in New Jersey on an overnight flight from a concert in Vancouver. "It was tough performing last night, knowing that I was going to ask the biggest question in my life to the most amazing girl in the world," he says. And while the news is bound to break a lot of young girls' hearts, the Jonas family couldn't be happier. "Our hearts are filled with joy today and we are happy to share with you that our son Kevin has asked Danielle for her hand in marriage," parents Denise and Kevin Jonas Sr. say in a statement to PEOPLE. "Her answer was yes, and it is such a blessing that she will be joining our family. Kevin and Danielle have not yet set a date. Family is very dear to us, and we hope we have raised Kevin to be a wonderful man and husband. Please join us in our family's celebration and in congratulating Kevin and Danielle. Thank you for all of your support." And younger brothers Joe and Nick said on their Twitter page: "Congrats big brother.....Dani welcome to the family, we can't wait to have you join us on the road!"

billy mays autopsy report


Billy Mays, who elevated the art of the television sales spiel to a fevered pitch, apparently died of a heart attack, Florida authorities said this morning.Preliminary autopsy results show that Mays suffered from hypertensive heart disease, Hillsborough County Medical Examiner Vernard Adams said during a televised news conference this morning. Toxicology and tissue tests will take several weeks before a final cause of death is issued, he said.
Mays, 50, was found dead in his Tampa home on Sunday after returning to Florida on a commercial flight that sustained a rough landing on Saturday. Mays had said that he had bumped his head during the touchdown.But Adams said the autopsy showed no evidence of trauma to the head, either external or internal.The autopsy showed that Mays' heart was heavier than normal because the left ventricle had enlarged, a symptom of heart disease, Adams said.
Adams said authorities had ruled out prescription drug abuse. Mays was taking prescription painkillers Tramadol and hydrocodone for hip pain, but the pill counts showed that Mays had taken the correct amount, according to the medical examiner

Omni Dual Saw


I was just telling myself the other day I need a more powerful saw. So naturally, like every American in the 21st century, I looked on the Internet. And lo, the gods answered by pointing me to an infomercial
My first thoughts upon beginning the Omni Dual Saw commercial: I wonder if this product is so unique and so powerful that it would take two presenters to tell me about it.
And lo! The gods delivered.The Omni Dual Saw comes with not one, but two announcers: Billy Mays (the man who brought you Oxi-clean, Might Putty, and KaBoom) and Anthony Sullivan (er, the man standing next to Billy Mays)! But if you order now they will throw in Ronco’s Ron Popeil for free!
Now, normally I think it is adorable when couples dress alike, but these two, with their matching khaki’s and denim shirts, put me in mind of Arnold Schwarzenegger and Danny DeVito’s stunt doubles for the movie “Twins”.
And as it turns out the Batman and Robin of TV sales addressed the exact problems I was having in my own personal sawing. Like the hapless handy man in the commercial; I was cutting lumber by wildly flailing my wood saw, trimming tubing by beating it to death with my hack saw, and slicing sheet metal by leering at it aggressively.
Well, as it turns out my problem was none of my saws are inspired by rescue technology. All my tools are inspired by the ingenuity of proud Amish laborers with their century year old unchanged designs. Luddites!
The commercial goes on to show how I can use this dual bladed wonder to cut through a car! This is perfect! You see, I drive a Hummer, but with gas prices as they are; it’s really time I switch to a more effecient mini. I think you see where I’m going with this.
Now cutting through cars is one thing, but is it easy to use? My lord, yes. On screen yelling pioneer Billy Mays explains how it is easy enough for anyone to use and then takes it one step further by showing that anyone can use it! Even a woman! A silly, silly woman! Aren’t they adorable when they try to do manual labor?
Yes, even women can use this saw to cut through their cars quicker than prunes through a short grandma. And it’s the counter rotational technology that makes this saw special. All this time I thought synchronized rotational technology was where the action was. This is truly the greatest thing since sliced bread, and who do you think sliced that bread? Billy Mays!

Obama’s Stance Deflects Chávez’s Finger-Pointing


CARACAS, Venezuela — From the moment the coup in Honduras unfolded over the weekend, President Hugo Chávez had his playbook ready. He said Washington’s hands may have been all over the ouster, claiming that it financed President Manuel Zelaya’s opponents and insinuating that the C.I.A. may have led a campaign to bolster the putschists.

But President Obama firmly condemned the coup, defusing Mr. Chávez’s charges. Instead of engaging in tit-for-tat accusations, Mr. Obama calmly described the coup as “illegal” and called for Mr. Zelaya’s return to office. While Mr. Chávez continued to portray Washington as the coup’s possible orchestrator, others in Latin America failed to see it that way.
“Obama Leads the Reaction to the Coup in Honduras,” read the front-page headline on Tuesday in Estado de São Paulo, one of the most influential newspapers in Brazil, whose ties to Washington are warm.
In recent years, Mr. Chávez has often seemed to outmaneuver Washington on such issues. He exploited the Bush administration’s low standing after the Iraq war and its tacit approval for the brief coup that toppled him in 2002, and blamed the United States for ills in Venezuela and across the region.
Now such tactics may get less traction, as the Obama administration presses for a multilateral solution to the crisis in Honduras by turning to the Organization of American States. In doing so, Mr. Obama is moving away from policies that had isolated the United States in parts of the hemisphere.
“With Honduras, the Obama administration has taken the mainstream road that is more in sync with other countries in the region,” said Peter DeShazo, director of the Americas program at the Center for Strategic and International Studies in Washington.
Honduras, which has long had close ties to Washington, has more recently emerged as a proxy for the interests of both Venezuela and the United States. With subsidized oil, Mr. Chávez lured Honduras into his leftist alliance, the Bolivarian Alternative for the Americas. Meanwhile, the United States did not cut off development and military aid to Honduras, in an attempt to maintain influence there.
But while Mr. Chávez has allies in Bolivia and Ecuador who succeeded in changing constitutions to stay in office longer — following his example in Venezuela — his intervention in Honduras heightened tension in that country. Reports that Venezuela sent a plane to Honduras last week with election material for a referendum at the heart of Mr. Zelaya’s clash with the Supreme Court stirred considerable unease there.
Mr. Chávez portrays his support for Mr. Zelaya as another example of championing his brand of democracy, which often centers on strong presidencies at the expense of other branches of government. But some countries in Latin America are resisting the trend of allowing leaders to extend their stay in office.
In Colombia, for instance, President Álvaro Uribe, a conservative populist and an American ally, is facing difficulties in a push to allow him to run for a third term. And in Argentina, the once popular former president, Néstor Kirchner, admitted defeat this week in congressional elections, throwing into doubt hopes for him and his wife, President Cristina Fernández de Kirchner, to extend their dynasty in the next presidential election.
Meanwhile, Mr. Obama is seeking to engage Brazil more deeply, reportedly floating the appointment of Luiz Inácio Lula da Silva, Brazil’s leftist president, as head of the World Bank. The move, if it materializes, would break the tradition of nominating an American to the post and could bolster support for Washington-based multilateral institutions while blunting Mr. Chávez’s attempts to create his own rival institutions.
Doing this while largely ignoring Mr. Chávez’s taunts holds risks for Mr. Obama, particularly if information comes to light showing that there is some truth in Mr. Chávez’s claims.
The Venezuelan president will not forget that the C.I.A. had knowledge of the coup that ousted him in 2002 yet did nothing to prevent it, and that Washington has a recent history of providing aid to groups that are critical of his government, opening the United States to charges of destabilization.
Moreover, Mr. Chávez’s antiestablishment rhetoric, aimed at elites in Washington and elsewhere, still resounds among many people here in Latin America.
But for now, at least, Mr. Obama’s nonconfrontational diplomacy seems to have caught Mr. Chávez off balance. “Chávez is beginning to understand that he’s dealing with someone with a very different approach than his predecessor,” said Michael Shifter, vice president of the Inter-American Dialogue, a Washington policy research group.
Mr. Chávez’s outsize role in the Honduras crisis, which involved threats of war if Venezuela’s Embassy in Honduras were searched, belies the limits of Venezuela’s influence in the hemisphere as the United States recalibrates its policies in a way that evokes the pragmatic diplomacy of the region’s other power, Brazil.
After the dust settles in Honduras, Mr. Chávez’s alliance will still include some of the region’s poorest and most conflict-ridden nations, like Bolivia and Nicaragua, with larger countries choosing other development paths.
Meanwhile, Mr. Chávez’s threats of belligerence in Central America led one opposition party here, Acción Democrática, to issue a statement on Monday that was full of irony: “Hugo Chávez has become the George Bush of Latin America.”

Franken’s Victory


After nearly eight months of waiting, almost 20,000 pages of legal briefs, and millions of dollars in election costs, Al Franken emerged Tuesday as the next United States senator from Minnesota, ending one of the most protracted election recount battles in recent memory.
Mr. Franken, 58, a former comedian and author, could be seated in the Senate as early as Monday, leaders there said, providing Democrats with something they had long hoped for: 60 votes, and thus at least the symbolic ability to overcome filibusters.
Norm Coleman, a Republican who had held the seat for a term, conceded on Tuesday afternoon, hours after the Minnesota Supreme Court issued a ruling in Mr. Franken’s favor, the latest in a series of findings that had left Mr. Franken ahead in the count. In weeks past, some Republican leaders had urged Mr. Coleman to press on to the federal courts if need be, but those calls faded Tuesday.
“Ours is a government of laws, not men and women,” Mr. Coleman, 59, said in a statement he read before reporters outside his home in St. Paul. “The Supreme Court of Minnesota has spoken, and I respect its decision and will abide by the result. It’s time for Minnesota to come together under the leaders it has chosen and move forward. I join all Minnesotans in congratulating our newest United States senator — Al Franken.”
It was an oddly abrupt ending to an election contest that had left Senator Amy Klobuchar, a Democrat, handling the state’s business alone and had left many ordinary Minnesotans weary of the fight.
All along, the candidates had been separated by the slightest of margins. With 2.9 million Minnesotans casting ballots last November, one early count showed Mr. Coleman ahead by 206 votes. Then, in a statewide hand recount set into motion by the close vote, the numbers fluctuated in the estimations of the campaigns and others trying to track them. Ultimately, a three-judge panel announced that Mr. Franken had won by 312 votes.
In issuing its 5-to-0 opinion, the Supreme Court found that Mr. Coleman, who had argued, in part, that thousands of absentee ballots had been wrongly excluded from the count, had failed to prove that “the trial court’s findings of fact are clearly erroneous or that the court committed an error of law or abused its discretion.”
Late Tuesday afternoon, outside his town house in downtown Minneapolis, Mr. Franken appeared jubilant at a news conference that at times looked more like an election-night rally. Passersby stopped, and one called out: “We have a senator! We have a senator!”
“When you win an election this close, you know that not one bit of effort went to waste,” said Mr. Franken, who has already hired senior staff to prepare for his transition to the Senate. His wife, Franni, had for months kept a packed suitcase at the ready like an expectant mother, Ms. Klobuchar said, should the family be called to Washington for a swearing-in.
President Obama called Mr. Franken to congratulate him on Tuesday, aides said, and he issued a statement saying he looked forward to working with the senator-elect “to build a new foundation for growth and prosperity by lowering health care costs and investing in the kind of clean energy jobs and industries that will help America lead in the 21st century.”
Gov. Tim Pawlenty, a Republican, signed Mr. Franken’s election certificate early Tuesday evening. Senate Democrats said they would like to seat Mr. Franken as quickly as next week, giving the party a crucial vote as it moves to difficult debates over topics like climate change and health care.
Democrats had held some committee posts for Mr. Franken, potentially including the Health, Education, Labor and Pensions Committee that is in the middle of drafting a health care overhaul.
With 60 votes (including those of two independents) now most likely aligned with the Democrats, the party could avoid filibusters.
But Mr. Franken swiftly made it clear that he did not view himself as the Democrats’ No. 60. “That’s not how I see it,” he said, adding that he was “going to be the second senator from the state of Minnesota, and that’s how I’m going to do this job.”
Though Republicans expressed disappointment at the outcome, they had in recent weeks become increasingly resigned to Mr. Franken joining the Senate.
On Tuesday, they joined Mr. Coleman in acknowledging defeat and immediately sought to raise expectations for Democrats.
“With their supermajority, the era of excuses and finger-pointing is now over,” said Senator John Cornyn of Texas, who heads the National Republican Senatorial Committee. Mr. Cornyn said it was “troubling to think about what they might now accomplish with 60 votes.”
But whether Democrats can consistently rely on 60 senators being present is in question. Two veteran Democrats, Senators Robert C. Byrd of West Virginia and Edward M. Kennedy of Massachusetts, are ailing and have regularly been absent from the Senate. In addition, a handful of moderate to conservative Democrats have shown a willingness to break from the party, and even liberals will do so on some issues.
In the Twin Cities, there was widespread relief on Tuesday. Minnesotans are viewed as among the nation’s most politically engaged and involved voters, but even there, patience had grown thin. “It went on forever,” Paul Mathey, 70, of St. Paul, complained.
The race was not the only long standoff in Senate history, nor was it the longest. Among others, the 1974 race between John A. Durkin and Louis C. Wyman left the Senate seat from New Hampshire in doubt for 10 months. The election was finally resolved when the seat was declared vacant and a special election was held, declaring Mr. Durkin, a Democrat, the winner in September 1975.
This time, the battle ended with a phone call between two men who had appeared to talk only through their opposing lawyers and spokesmen for months.
On Tuesday afternoon, Mr. Coleman called Mr. Franken to tell him he was giving up. Mr. Coleman, who some in Minnesota were already speculating might run for governor in 2010 (for now, he would not comment) described the call as “a very personal discussion, a very positive discussion.”
Mr. Franken said that the two had talked about the difficulty of the long fight on their families, and that Mr. Coleman had told him, “This is going to be the best job you’ll ever have.”
After so much turmoil, the phone call was warm and gracious, Mr. Franken said, adding later that he had recalled thinking in the midst of it: “This is nice. This is a nice way to end it.”